In Search of Giant Squid has been developed by the National Museum of Natural History and the Smithsonian Institution Traveling Exhibition Service (SITES) in partnership with the Discovery Channel, and is made possible by the National Aeronautics and Space Administration and the National Oceanic and Atmospheric Administration (NOAA).

Local sponsorship has been generously provided by The Boeing Company, Ivar's Salmon House, Microsoft Corporation, and US Bancorp Foundation.